SERA - Antibody Repertoire Analysis
Broadly profile antibody repertoires and identify antigens and epitopes associated with cancer, autoimmune, infectious disease, drug response and more.
Why SERA Antibody Profiling?
Develop immune profile signatures to identify disease / antigen associations
Patient stratification - correlate immune response with clinical outcomes
High resolution - identify specific epitopes and motifs
View the diversity of the immune response across samples of interest
Detect autoantibodies or antibodies against drugs / vectors
Serum Epitope Repertoire Analysis (SERA) Platform
Combining universal chemistry with proprietary informatics, SERA assesses antibody repertoires to address research and clinical needs.
Data Analysis
Our bioinformatics pipeline identifies epitopes and motifs associated with disease or any perturbation observed by the immune system.
The signals observed in the assay can then be used to understand the immune profiles between individuals and cohorts to compare disease vs normal states to identify different immune profiles.
The SERA Assay can identify specific antigenic epitopes.
The recognized peptide sequences can be arranged in a heatmap to demonstrate the differences or similarities across samples.
Applications
SERA can be applied across multiple areas of research.
Oncology
Autoimmune
Vaccines
Infectious Disease
Presentation
Download our presentation to see how the SERA Platform was utilized to identify antibody epitopes induced by Moderna’s mRNA COVID19 Vaccine and Boosters.
Customer Provides:
50 ul of serum or plasma per sample.
Minimal information about the samples.
Serimmune analyzes each sample for IgG antibodies using its 10 billion member, random 12mer, bacterial peptide display library.
Serimmune performs epitope analysis across the entire proteome using its proprietary IMUNE and PIWAS methodologies.
Serimmune provides summary data and visualizations for each sample, including raw data for subsequent customer analysis.
