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COVID Epitope Mapping Discovery Service

Working with collaborators and partners, Serimmune has processed and analyzed the epitope repertoires of over 15,000 subjects, including more than 1,000 SARS-CoV-2 samples.

Due to strong demand for access to the SERA technology to better understand the antibody response to SARS-CoV-2 vaccination and natural infection, Serimmune has launched a COVID epitope mapping discovery service.

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How it Works

Customer Provides:

  • 100 ul of serum or plasma per sample
  • Minimal information about the samples

Serimmune:

Analyzes each sample for IgG antibodies using its 10 billion member, random 12mer, bacterial peptide display library

Analyzes each sample for IgG or IgM antibodies using its 10 billion member, random 12mer, bacterial peptide display library

Performs epitope analysis across the entire SARS-CoV-2 Proteome using its proprietary IMUNE and PIWAS methodologies

Performs epitope analysis across the entire SARS-CoV-2 Proteome using its proprietary IMUNE and PIWAS methodologies

Provides summary data and visualizations for each sample, including raw data for subsequent customer analysis

Provides summary data and visualizations for each sample, including raw data for subsequent customer analysis

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For Each Sample the Customer Receives:

A composite score that compares the antibody epitopes identified in each sample to those observed in cohorts of individuals with mild, moderate and severe COVID=19 disease
A composite score that compares the antibody epitopes identified in each sample to those observed in cohorts of individuals with mild, moderate and severe COVID-19 disease
A list of motifs that are known to be enriched in SARS-CoV-2 positive subjects and the related enrichment scores in that sample
A list of motifs that are known to be enriched in SARS-CoV-2 positive subjects and the related enrichment scores in each sample
Epitope tiling data across the entire SARS-CoV-2 proteome and how this compared with a large cohort of healthy controls; all in an easy-to-interpret, interactive html format.
Epitope tiling data across the entire SARS-CoV-2 proteome and how this compares with a large cohort of pre-pandemic controls and SARS-COV-2 positive samples; all in an easy-to-interpret, interactive html format.
Raw data that includes Motifs with Enrichment Scores and IWAS values for each amino acid in the SARS-CoV-2 proteome to allow for more in-depth analysis by the customer.
Raw data that includes Motifs with Enrichment Scores and IWAS values for each amino acid in the SARS-CoV-2 proteome to allow for more in-depth analysis by the customer.
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Two Ways to Work With Us

To meet the needs of both our academic and biopharma customers we offer two different models.


Data Sharing Model

Data Sharing Model<
  • Customer provides minimal, de-identified information about the samples (e.g. sex, age, disease status).
  • Serimmune generates data and customer can use for its own purposes. Serimmune shares the data.
  • Significantly reduced price per sample.

Fee-For-Service Model

Fee-For-Service Model
  • Customer sharing of information about the samples is optional
  • Customer owns data and results
  • Standard pricing
  • Option to add additional analysis services

To learn more about this service or to discuss a potential project and receive a quote, please contact us.

Contact

For Research Use Only. Not for use in diagnostic procedures.

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