Sample Summary Report
Order: SAMPLE1234
External identifier: SAMPLE1234
This report summarizes the results of the SERA SARS-CoV-2 research assay on sample SAMPLE1234.
IgG
Motif data
The SERA IgG panel includes 52 motifs and features that were identified as sensitive and specific to the COVID patient poulation (n > 500) relative to a large, pre-pandemic database of controls (n > 2000). A subset of these motifs map linearly to SARS-CoV-2 antigens (i.e. nucleoprotein, spike). The non-mapping motifs likely represent mimotopes of structural epitopes to SARS-CoV-2. Individual motif enrichments for the sample (black) are shown relative to the pre-pandemic controls (grey).
IgG SARS-CoV-2 tiling plots
The PIWAS tool was applied to provide amino acid resolution tiling data for the entirety of the SARS-CoV-2 proteome (Uniprot proteome: UP000464024). The plots below provide this tiling information for the sample (black) relative the the 5th-95th quantile bands for the COVID patients (purple) and controls (grey). The first plot show spike glycoprotein annotated with important functioning sites along its amino acid sequence. Abbreviations: Signal Peptide (SP), N-terminal domain (NTD), receptor-binding domain (RBD), fusion peptide (FP), internal fusion peptide (IFP), two heptad-repeat domains (HR1 and HR2), transmembrane protein (TM), and C-terminal domain (CT). HTML plots are interactive. You may: mouse over to see values, click and drag to zoom, and double click to un-zoom. For the legend you can select and de-select any series by clicking on the label under Sample Comparison Cohorts.
The following page shows the PIWAS tiling of the remainder of the SARS-CoV-2 Proteins.